Tool Compound Libary (TCL)

The Tool Compound Library (TCL) is an existing collection of modified small molecules with known targets with a proper size and shape linker (the modified molecule retains the mother compound’s activity against the target), for specific approaches.

Name Structure Reference
AX14596 1, 2, 4, 6
VI16832 VI18632 1, 3, 4
SU6668 SU6668 1, 4, 5
Bisindolylmaleimide X Bisindolylmaleimide X 1, 4, 6
Purvalanol B Purvalanol B 1, 4, 6
VI16743 VI16743 3
VI16741 VI16741 3, 4
PP58 PP58 6

Vichem has an existing collection of more than 300 kinase inhibitors equipped with primary amine-, carboxyl-, acetylene- or azide- function ending linkers.

Each member of this library can be used for:

  • specific biological assays (with fluorescent dye labeling) e.g. determination of slow binding kinetics
  • affinity chromatography (bound to a column) to pull down protein targets
  • targeted delivery (bound to different types of carriers, synthetic polymers, peptides, proteins etc.).

Examples for published affinitiy chromatograpy applications of TCL compounds for target identification are in the table.

References

  1. Molecular Cell 31, 438, 2008
  2. Cancer Res 65: (2), 379, 2005
  3. Mol Cell Proteomics 8, 1751, 2009
  4. Mol Cell Proteomics 9, 1047, 2010
  5. Cancer Res 65: (15), 6919, 2005
  6. Mol Cell Proteomics 6, 537, 2006

If you have any further questions, please do not hesitate to contact us: info@vichem.hu